Neurologists Exam Neurologists Exam Neurodegenerative & Movement Disorders 1

Question 1

The triad of resting tremor, rigidity, and bradykinesia is classic for which neurodegenerative disorder?

Accepted Answer

Parkinson's disease

Answer

Parkinson's disease is characterized by the cardinal motor triad of resting tremor, cogwheel rigidity, and bradykinesia due to dopaminergic neuron loss.

Question 2

Which protein aggregate is the pathological hallmark found in Lewy body dementia and Parkinson's disease?

Accepted Answer

Alpha-synuclein (Lewy bodies)

Answer

Lewy bodies are intraneuronal aggregates of misfolded alpha-synuclein protein, defining the neuropathology of Parkinson's disease and LBD.

Question 3

Huntington's disease is caused by a CAG trinucleotide repeat expansion in which gene?

Accepted Answer

HTT (huntingtin)

Answer

Huntington's disease results from a CAG repeat expansion (>36 repeats) in the HTT gene encoding the huntingtin protein on chromosome 4.

Question 4

Which finding on neuroimaging is most characteristic of multiple system atrophy (MSA-P subtype)?

Accepted Answer

Putaminal atrophy with T2 hypointensity and rim sign

Answer

MSA-P shows putaminal atrophy with T2 hypointensity and a hyperintense lateral rim (hot cross bun sign in MSA-C) on MRI.

Question 5

The DaTscan (dopamine transporter scan) is used to differentiate Parkinson's disease from which condition?

Accepted Answer

Essential tremor

Answer

DaTscan shows reduced dopamine transporter uptake in PD but is normal in essential tremor, helping distinguish these two tremor disorders.

Neurologists Exam Practice Test

Neurologists Exam Practice Test

Neurologists Exam Neurologists Exam Neurodegenerative & Movement Disorders 1