MBBS Pathology 2

Question 1

Which genetic mutation is associated with chronic myeloid leukemia (CML)?

Accepted Answer

BCR-ABL fusion t(9;22) Philadelphia chromosome

Answer

CML is characterized by the Philadelphia chromosome, resulting from t(9;22) translocation creating BCR-ABL fusion, a constitutively active tyrosine kinase.

Question 2

What is the most common cause of community-acquired pneumonia (CAP) in adults?

Accepted Answer

Streptococcus pneumoniae

Answer

Streptococcus pneumoniae is the most common cause of bacterial community-acquired pneumonia in adults across all age groups.

Question 3

Which histological finding is characteristic of Crohn's disease but NOT ulcerative colitis?

Accepted Answer

Non-caseating granulomas

Answer

Non-caseating granulomas are found in approximately 50% of Crohn's disease cases and represent a hallmark distinguishing it from ulcerative colitis.

Question 4

Mallory bodies (Mallory-Denk bodies) in hepatocytes are associated with which condition?

Accepted Answer

Alcoholic liver disease

Answer

Mallory bodies are aggregates of cytokeratin intermediate filaments found in hepatocytes damaged by alcohol, representing a hallmark of alcoholic hepatitis.

Question 5

Which cell type is the primary effector in granuloma formation?

Accepted Answer

Epithelioid macrophages and giant cells

Answer

Granulomas consist primarily of activated epithelioid macrophages and multinucleated giant cells, organized to wall off persistent antigens.

MBBS - Bachelor of Medicine and Bachelor of Surgery Practice Test

MBBS - Bachelor of Medicine and Bachelor of Surgery Practice Test

MBBS Pathology 2