MBBS Pathology 2

Question 1

Which genetic mutation is associated with chronic myeloid leukemia (CML)?

Accepted Answer

BCR-ABL fusion t(9;22) Philadelphia chromosome

Answer

BCL-2 translocation t(14;18)

Answer

MYC translocation t(8;14)

Answer

PML-RARA fusion t(15;17)

Question 2

What is the most common cause of community-acquired pneumonia (CAP) in adults?

Accepted Answer

Streptococcus pneumoniae

Answer

Mycoplasma pneumoniae

Answer

Haemophilus influenzae

Answer

Legionella pneumophila

Question 3

Which histological finding is characteristic of Crohn's disease but NOT ulcerative colitis?

Accepted Answer

Non-caseating granulomas

Answer

Crypt abscesses

Answer

Goblet cell depletion

Answer

Mucosal inflammation

Question 4

Mallory bodies (Mallory-Denk bodies) in hepatocytes are associated with which condition?

Accepted Answer

Alcoholic liver disease

Answer

Viral hepatitis B

Answer

Primary biliary cirrhosis

Answer

Hemochromatosis

Question 5

Which cell type is the primary effector in granuloma formation?

Accepted Answer

Epithelioid macrophages and giant cells

Answer

Neutrophils

Answer

NK cells

Answer

Plasma cells

Question 6

Psammoma bodies are calcified concentric rings found in which tumor?

Accepted Answer

Papillary thyroid carcinoma

Answer

Glioblastoma multiforme

Answer

Small cell lung cancer

Answer

Hepatocellular carcinoma