MBBS Pathology 1 — Questions and Answers
Question 1: Which type of necrosis is characteristically seen in tuberculosis?
- Liquefactive necrosis
- Coagulative necrosis
- Caseous necrosis (Correct answer)
- Fat necrosis
Correct answer: Caseous necrosis
Tuberculosis produces caseous necrosis, which appears cheese-like grossly and consists of amorphous pink granular material microscopically.
Question 2: Reed-Sternberg cells are pathognomonic of which condition?
- Non-Hodgkin lymphoma
- Hodgkin lymphoma (Correct answer)
- Chronic lymphocytic leukemia
- Burkitt lymphoma
Correct answer: Hodgkin lymphoma
Reed-Sternberg cells (large binucleated cells with prominent 'owl eye' nucleoli) are the hallmark of Hodgkin lymphoma.
Question 3: Which tumor marker is elevated in hepatocellular carcinoma?
- CEA
- CA 19-9
- Alpha-fetoprotein (AFP) (Correct answer)
- PSA
Correct answer: Alpha-fetoprotein (AFP)
AFP is elevated in approximately 70% of hepatocellular carcinoma cases and is also elevated in yolk sac tumors.
Question 4: What is the most common cause of right heart failure in the United States?
- Pulmonary embolism
- Left heart failure (Correct answer)
- Primary pulmonary hypertension
- Tricuspid regurgitation
Correct answer: Left heart failure
Left heart failure leading to pulmonary hypertension and right ventricular pressure overload is the most common cause of right heart failure.
Question 5: Amyloid deposits in systemic amyloidosis are identified with which stain?
- Periodic acid-Schiff (PAS)
- Congo red with apple-green birefringence under polarized light (Correct answer)
- Prussian blue
- Oil Red O
Correct answer: Congo red with apple-green birefringence under polarized light
Congo red stain identifies amyloid deposits, which show characteristic apple-green birefringence under polarized light microscopy.
Question 6: Which of the following is an example of Type III hypersensitivity (immune complex-mediated)?
- Anaphylaxis
- Goodpasture syndrome
- Serum sickness (Correct answer)
- Contact dermatitis
Correct answer: Serum sickness
Serum sickness is a Type III (immune complex-mediated) hypersensitivity reaction where antigen-antibody complexes deposit in vessel walls and tissues.
MBBS Pathology 1
Which type of necrosis is characteristically seen in tuberculosis?