A 48-year-old man presents with massive pleural effusion. Thoracentesis reveals exudative fluid (LDH 380 U/L, protein 4.2 g/dL, pH 7.15, glucose 42 mg/dL). Gram stain is negative, but culture grows Streptococcus milleri. What is the MOST appropriate next management step?
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A
IV antibiotics alone with repeat thoracentesis in 48 hours
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B
Chest tube drainage plus IV antibiotics
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C
Thoracoscopy with decortication
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D
Intrapleural tPA plus DNase