IBD IBD Pathophysiology 2

Question 1

Which immune cell type is primarily responsible for the IL-17 driven response seen in IBD?

Accepted Answer

Th17 cells

Answer

Th17 cells produce IL-17 and contribute to the mucosal inflammatory cascade, particularly in Crohn's disease pathogenesis.

Question 2

What is the role of regulatory T cells (Tregs) in IBD pathogenesis?

Accepted Answer

They suppress excessive mucosal immune activation

Answer

Tregs normally suppress excessive immune activation in the gut mucosa; their dysfunction or deficiency contributes to the uncontrolled inflammation seen in IBD.

Question 3

Which barrier function is disrupted in IBD, leading to increased intestinal permeability?

Accepted Answer

Mucus layer and tight junctions

Answer

Disruption of the mucus layer and tight junction proteins (e.g., claudins, occludin) increases intestinal permeability, allowing luminal antigens to trigger inflammation.

Question 4

In UC, the histological finding of 'crypt abscesses' involves accumulation of which cells within crypts?

Accepted Answer

Neutrophils

Answer

Crypt abscesses in UC are characterized by neutrophil accumulation within the crypts of Lieberkühn, reflecting acute active inflammation.

Question 5

The mesenteric 'fat wrapping' (creeping fat) is a gross pathological feature of which IBD condition?

Accepted Answer

Crohn's disease

Answer

Creeping fat — mesenteric adipose tissue wrapping around the bowel — is a macroscopic hallmark of transmural Crohn's disease inflammation.

IBD - Inflammatory Bowel Disease Practice Test

IBD - Inflammatory Bowel Disease Practice Test

IBD IBD Pathophysiology 2