IBD IBD Pathophysiology 2

Question 1

Which immune cell type is primarily responsible for the IL-17 driven response seen in IBD?

Accepted Answer

Th17 cells

Answer

Th1 cells

Answer

Th2 cells

Answer

Treg cells

Question 2

What is the role of regulatory T cells (Tregs) in IBD pathogenesis?

Accepted Answer

They suppress excessive mucosal immune activation

Answer

They amplify the inflammatory response

Answer

They produce TNF-α directly

Answer

They destroy intestinal goblet cells

Question 3

Which barrier function is disrupted in IBD, leading to increased intestinal permeability?

Accepted Answer

Mucus layer and tight junctions

Answer

Peyer's patches only

Answer

Muscularis mucosae

Answer

Mesenteric lymph nodes

Question 4

In UC, the histological finding of 'crypt abscesses' involves accumulation of which cells within crypts?

Accepted Answer

Neutrophils

Answer

Lymphocytes

Answer

Eosinophils

Answer

Plasma cells

Question 5

The mesenteric 'fat wrapping' (creeping fat) is a gross pathological feature of which IBD condition?

Accepted Answer

Crohn's disease

Answer

Ulcerative colitis

Answer

Microscopic colitis

Answer

Diversion colitis

Question 6

Which environmental factor has been most consistently shown to be protective against ulcerative colitis?

Accepted Answer

Cigarette smoking

Answer

High-fiber diet

Answer

Urban residence

Answer

Appendectomy in childhood