IBD IBD Pathophysiology

Question 1

Which cytokine is predominantly elevated in Crohn's disease and drives the Th1 immune response?

Accepted Answer

TNF-α and IFN-γ

Answer

IL-4 and IL-13

Answer

IL-5 and IL-9

Answer

TGF-β and IL-10

Question 2

In ulcerative colitis, inflammation characteristically begins at which anatomical location?

Accepted Answer

Rectum

Answer

Terminal ileum

Answer

Ascending colon

Answer

Sigmoid colon

Question 3

Which layer of the intestinal wall is primarily involved in ulcerative colitis inflammation?

Accepted Answer

Mucosa and submucosa

Answer

Serosa and adventitia

Answer

Muscularis propria only

Answer

All layers (transmural)

Question 4

Non-caseating granulomas on biopsy are pathognomonic of which IBD condition?

Accepted Answer

Crohn's disease

Answer

Ulcerative colitis

Answer

Indeterminate colitis

Answer

Microscopic colitis

Question 5

Which genetic mutation is most strongly associated with Crohn's disease susceptibility?

Accepted Answer

NOD2/CARD15

Answer

HLA-B27

Answer

MEFV

Answer

CFTR

Question 6

The 'skip lesion' pattern of bowel involvement is a hallmark feature of which IBD type?

Accepted Answer

Crohn's disease

Answer

Ulcerative colitis

Answer

Ischemic colitis

Answer

Infectious colitis