IBD IBD Complications and Extraintestinal Manifestations

Question 1

Which extraintestinal manifestation of IBD runs a course parallel to (mirrors) intestinal disease activity?

Accepted Answer

Peripheral arthropathy (type 1, pauciarticular)

Answer

Primary sclerosing cholangitis (PSC)

Answer

Ankylosing spondylitis

Answer

Uveitis

Question 2

Primary sclerosing cholangitis (PSC) is most strongly associated with which IBD condition?

Accepted Answer

Ulcerative colitis (particularly pancolitis)

Answer

Crohn's disease of the small bowel

Answer

Gastroduodenal Crohn's disease

Answer

Microscopic colitis

Question 3

Erythema nodosum in IBD presents as which type of skin lesion?

Accepted Answer

Painful, tender, raised red/purple nodules typically on the anterior shins

Answer

Painless, raised violet plaques on the shins

Answer

Vesicular eruption following dermatomes

Answer

Flat, hyperpigmented macules on the trunk

Question 4

Pyoderma gangrenosum (PG) in IBD differs from erythema nodosum because PG characteristically:

Accepted Answer

May occur independently of IBD activity and requires specific wound care plus immunosuppression

Answer

Correlates directly with IBD disease activity

Answer

Heals without scarring after treating the underlying IBD

Answer

Only occurs on the anterior shins

Question 5

Venous thromboembolism (VTE) risk in IBD patients is elevated primarily because of which mechanism?

Accepted Answer

Hypercoagulable state from chronic inflammation, elevated factor VIII, fibrinogen, and reduced protein C/S

Answer

Anticoagulant protein deficiency only

Answer

Immobility alone

Answer

Steroid-induced platelet destruction

Question 6

Gallstones (cholelithiasis) are more common in Crohn's disease affecting the terminal ileum due to which mechanism?

Accepted Answer

Impaired bile acid reabsorption leading to supersaturated bile with cholesterol stone formation

Answer

Increased cholesterol absorption from inflamed ileum

Answer

Elevated bilirubin from hemolytic anemia

Answer

Antibiotic-induced biliary microbiome changes