GTS Soft Tissue Pathology & Fibrosis Flashcards

What is the term for the excessive and disorganized deposition of collagen that forms after soft tissue trauma?

Answer: Fibrosis

Fibrosis refers to the excessive and disorganized deposition of collagen that can occur after soft tissue trauma, leading to restricted mobility and altered function.

In the context of soft tissue pathology, what does the term 'adhesion' refer to?

Answer: Abnormal fibrous connections between adjacent tissue layers

An adhesion is an abnormal fibrous connection that forms between adjacent tissue layers, restricting their normal gliding and movement.

Which cytokine is most commonly associated with promoting fibroblast proliferation and collagen synthesis after injury?

Answer: Transforming Growth Factor-beta (TGF-β)

Transforming Growth Factor-beta (TGF-β) is a key cytokine that promotes fibroblast proliferation, collagen synthesis, and scar formation following tissue injury.

What percentage of musculoskeletal injuries involve fascia or connective tissue according to common Graston Technique literature?

Answer: Greater than 85%

According to Graston Technique educational materials, greater than 85% of musculoskeletal injuries involve fascia or connective tissue, justifying soft tissue mobilization approaches.

What structural characteristic distinguishes scar tissue from normal soft tissue?

Answer: Random, multidirectional collagen fiber orientation

Scar tissue is distinguished from normal tissue by its random, multidirectional collagen fiber orientation, compared to the organized, parallel alignment found in healthy tissue.

Which of the following conditions is most commonly associated with pathological soft tissue fibrosis in athletic populations?

Answer: Repetitive microtrauma leading to tendinopathy

Repetitive microtrauma leading to tendinopathy is the most common cause of pathological soft tissue fibrosis in athletic populations due to accumulated micro-damage exceeding repair capacity.