GI GI Disorders and Diseases 3

Question 1

In irritable bowel syndrome (IBS), which diagnostic criteria are currently used?

Accepted Answer

Rome IV criteria

Answer

The Rome IV criteria define IBS as recurrent abdominal pain at least 1 day/week for 3 months, associated with defecation or stool changes.

Question 2

Peutz-Jeghers syndrome is characterized by GI hamartomatous polyps and mucocutaneous pigmentation, and carries increased risk of malignancy in which gene mutation?

Accepted Answer

STK11 (LKB1) gene

Answer

Peutz-Jeghers syndrome is caused by germline mutations in STK11 (LKB1), a tumor suppressor gene on chromosome 19p.

Question 3

Which of the following features distinguishes acute mesenteric ischemia from other causes of acute abdomen?

Accepted Answer

Pain out of proportion to physical exam findings

Answer

A classic hallmark of acute mesenteric ischemia is severe abdominal pain that is disproportionately greater than the physical examination findings.

Question 4

Hereditary hemochromatosis most commonly results from a mutation in which gene, leading to iron overload and hepatic cirrhosis?

Accepted Answer

HFE

Answer

Most hereditary hemochromatosis in the US is caused by the C282Y homozygous mutation in the HFE gene on chromosome 6p.

Question 5

Which type of viral hepatitis is transmitted via the fecal-oral route and does NOT cause chronic infection?

Accepted Answer

Hepatitis A

Answer

Hepatitis A is transmitted by the fecal-oral route and causes only acute infection, with no chronic carrier state.

Gastrointestinal GI Practice Practice Test

Gastrointestinal GI Practice Practice Test

GI GI Disorders and Diseases 3