FPGEE Pharmacy Practice 3

Question 1

A patient is prescribed lithium for bipolar disorder. Which condition increases the risk of lithium toxicity?

Accepted Answer

Dehydration

Answer

Dehydration reduces renal lithium clearance, causing accumulation and toxicity since lithium is renally excreted without protein binding.

Question 2

Which schedule of controlled substances has the HIGHEST accepted medical use but LOWEST potential for abuse?

Accepted Answer

Schedule V

Answer

Schedule V substances (e.g., cough preparations with <200 mg codeine per 100 mL) have low abuse potential and accepted medical uses.

Question 3

A pharmacist checks a new prescription for ciprofloxacin and notes the patient is also taking sucralfate. What interaction should be addressed?

Accepted Answer

Sucralfate chelates ciprofloxacin, reducing its absorption

Answer

Sucralfate forms insoluble chelates with ciprofloxacin, significantly reducing its oral bioavailability by up to 90%.

Question 4

What is the maximum daily acetaminophen dose recommended for a healthy adult to avoid hepatotoxicity?

Accepted Answer

4,000 mg

Answer

The FDA-recommended maximum acetaminophen dose for healthy adults is 4,000 mg per day, though 3,000 mg is advised for chronic use.

Question 5

Which route of administration completely bypasses first-pass hepatic metabolism?

Accepted Answer

Intravenous

Answer

Intravenous administration delivers drugs directly into systemic circulation, completely bypassing first-pass hepatic metabolism.

FPGEE Exam Practice Test