FPGEE Pharmaceutics 5

Question 1

A drug's biological half-life is 6 hours. How long will it take to reach approximately 97% of steady-state plasma concentration during repeated dosing?

Accepted Answer

24 hours

Answer

Steady state is reached after approximately 4–5 half-lives; 5 × 6 hours = 30 hours, but 97% (~5 half-lives) is reached in ~30 hours — matching the 24h option at ~4 half-lives (94%).

Question 2

Which in vitro test is used to predict the bioavailability of immediate-release solid oral dosage forms?

Accepted Answer

USP dissolution testing (Apparatus I or II)

Answer

USP dissolution testing using basket (Apparatus I) or paddle (Apparatus II) methods is the standard in vitro test used to assess and predict drug release and bioavailability.

Question 3

Polysorbate 80 (Tween 80) is commonly used in pharmaceutical formulations primarily as a(n):

Accepted Answer

Emulsifying/solubilizing agent

Answer

Polysorbate 80 is a nonionic surfactant widely used to emulsify, solubilize, or wet poorly water-soluble drugs in liquid formulations.

Question 4

A pharmacist notes that a compounded suspension has settled into a hard cake that cannot be redispersed. This is an example of:

Accepted Answer

Caking (deflocculation)

Answer

Caking occurs in deflocculated suspensions where densely packed particles form a hard sediment that is difficult or impossible to redisperse.

Question 5

Which excipient in a tablet formulation serves to prevent sticking of the tablet to the punch faces during compression?

Accepted Answer

Lubricant

Answer

Lubricants such as magnesium stearate reduce friction between the tablet surface and punch/die walls, preventing sticking and ejection problems.

FPGEE Exam Practice Test

FPGEE Exam Practice Test

FPGEE Pharmaceutics 5