FPGEE Pharmaceutical Chemistry 2

Question 1

Which functional group is responsible for the acidic properties of aspirin?

Accepted Answer

Carboxylic acid group

Answer

The carboxylic acid (-COOH) group in aspirin (acetylsalicylic acid) donates a proton, conferring its acidic properties.

Question 2

The term 'prodrug' refers to a compound that:

Accepted Answer

Requires metabolic conversion to exert its effect

Answer

A prodrug is pharmacologically inactive until metabolized in the body to its active form.

Question 3

Which bond type is hydrolyzed during the metabolism of ester prodrugs?

Accepted Answer

Ester bond

Answer

Esterases in plasma and tissues cleave the ester bond, releasing the active drug from an ester prodrug.

Question 4

The Henderson-Hasselbalch equation is used primarily to predict:

Accepted Answer

The degree of ionization of a drug at a given pH

Answer

The Henderson-Hasselbalch equation relates pH, pKa, and the ratio of ionized to unionized drug forms.

Question 5

Which class of reaction is CYP3A4-mediated hydroxylation classified as?

Accepted Answer

Phase I oxidation

Answer

CYP3A4 is a cytochrome P450 enzyme that catalyzes Phase I oxidation reactions, including aromatic and aliphatic hydroxylation.

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