FPGEE FPGEE Exam 3

Question 1

A patient develops signs of serotonin syndrome after being prescribed linezolid while already on sertraline. Which symptom BEST distinguishes serotonin syndrome from neuroleptic malignant syndrome?

Accepted Answer

Hyperreflexia and clonus

Answer

Hyperreflexia and clonus are hallmark features of serotonin syndrome and are generally absent in neuroleptic malignant syndrome, which features lead-pipe rigidity instead.

Question 2

Which class of antihypertensives is CONTRAINDICATED in bilateral renal artery stenosis?

Accepted Answer

ACE inhibitors

Answer

ACE inhibitors (and ARBs) block angiotensin II-mediated efferent arteriolar constriction, which is the compensatory mechanism maintaining GFR in bilateral renal artery stenosis, leading to acute kidney injury.

Question 3

A drug has a half-life of 8 hours. How long will it take to reach approximately 94% of steady-state concentration with regular dosing?

Accepted Answer

32 hours

Answer

It takes approximately 4 half-lives to reach ~94% of steady state; 4 × 8 hours = 32 hours.

Question 4

Which antiepileptic drug works primarily by blocking voltage-gated sodium channels and is first-line for focal seizures?

Accepted Answer

Carbamazepine

Answer

Carbamazepine blocks voltage-gated sodium channels, stabilizing neuronal membranes, and is a first-line agent for focal (partial) seizures.

Question 5

A compounding pharmacist needs to prepare an isotonic solution. What is the approximate freezing point depression of normal saline (0.9% NaCl)?

Accepted Answer

-0.52°C

Answer

Normal saline (0.9% NaCl) has a freezing point depression of -0.52°C, which equals the freezing point depression of blood, making it isotonic.

FPGEE Exam Practice Test

FPGEE Exam Practice Test

FPGEE FPGEE Exam 3