FPGEE Clinical Pharmacy 4

Question 1

A patient with severe penicillin allergy (anaphylaxis) requires treatment for a gram-negative infection. Which beta-lactam has the lowest cross-reactivity risk?

Accepted Answer

Aztreonam

Answer

Aztreonam is a monobactam with a different ring structure and exhibits negligible cross-reactivity with penicillins.

Question 2

A 55-year-old patient has a calculated 10-year ASCVD risk of 12%. Which statin intensity is recommended per ACC/AHA guidelines?

Accepted Answer

Moderate-intensity statin

Answer

A 10-year ASCVD risk ≥7.5% in patients aged 40–75 without clinical ASCVD warrants a moderate- to high-intensity statin; 12% falls in the moderate-to-high discussion zone with moderate typically initiated first.

Question 3

Which finding on a patient's medication history would prompt a pharmacist to question the appropriateness of prescribing an NSAID?

Accepted Answer

History of peptic ulcer disease

Answer

A history of peptic ulcer disease is a major contraindication to NSAID use due to risk of GI bleeding and ulcer recurrence.

Question 4

A patient is taking carbamazepine and is prescribed oral contraceptives. What counseling should be provided?

Accepted Answer

Carbamazepine may reduce OC effectiveness; use backup contraception

Answer

Carbamazepine is a potent CYP3A4 inducer that accelerates metabolism of estrogen and progestin, reducing contraceptive efficacy.

Question 5

What is the primary mechanism of action of proton pump inhibitors (PPIs)?

Accepted Answer

Irreversible inhibition of H+/K+-ATPase

Answer

PPIs covalently and irreversibly bind the H+/K+-ATPase enzyme on the parietal cell, blocking the final step of acid secretion.

FPGEE Exam Practice Test

FPGEE Exam Practice Test

FPGEE Clinical Pharmacy 4