A patient on an SSRI develops agitation, tremor, diaphoresis, hyperreflexia, and clonus within hours of adding tramadol. How does serotonin syndrome differ from Neuroleptic Malignant Syndrome?
-
A
NMS has clonus while serotonin syndrome has lead-pipe rigidity
-
B
Serotonin syndrome has rapid onset with clonus; NMS has slower onset with lead-pipe rigidity
-
C
NMS is caused by serotonergic agents; serotonin syndrome by antipsychotics
-
D
They are clinically indistinguishable without laboratory testing