Recombinant human growth hormone (rhGH) therapy is sometimes used in children with CKD-related growth failure. Which nutritional PREREQUISITE must be met before initiating rhGH to ensure optimal response?
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A
Serum potassium must be > 5.0 mEq/L before starting rhGH
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B
Adequate nutritional status must be optimized (meeting calorie and protein targets, correcting metabolic acidosis, normalizing CKD-MBD) — as rhGH is ineffective in the presence of severe malnutrition or uncontrolled metabolic derangements
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C
rhGH can be started at any nutritional status; it overcomes all nutritional deficits
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D
rhGH is only effective in children with normal serum albumin > 4.5 g/dL