CSR CSR Pharmacology & Drug-Nutrient Interactions in Renal Disease 2

Question 1

Cinacalcet (a calcimimetic) lowers PTH levels by activating which receptor on parathyroid gland cells?

Accepted Answer

Calcium-sensing receptor (CaSR)

Answer

Cinacalcet activates the calcium-sensing receptor on parathyroid cells, suppressing PTH secretion.

Question 2

Which adverse electrolyte effect is associated with the potassium binder patiromer due to nonselective GI binding?

Accepted Answer

Hypomagnesemia

Answer

Patiromer can bind magnesium in the GI tract in addition to potassium, leading to hypomagnesemia.

Question 3

Which antibiotic class requires significant dose reduction in CKD because it is renally cleared and nephrotoxic?

Accepted Answer

Aminoglycosides

Answer

Aminoglycosides are renally cleared and intrinsically nephrotoxic, requiring dose adjustment to prevent accumulation in CKD.

Question 4

Sodium bicarbonate supplementation in CKD is primarily used to treat which acid-base disturbance?

Accepted Answer

Metabolic acidosis

Answer

Sodium bicarbonate corrects metabolic acidosis, which is common in advanced CKD due to reduced renal acid excretion.

Question 5

Which phosphate binder contains iron as its active binding component and may contribute to iron stores?

Accepted Answer

Sucroferric oxyhydroxide

Answer

Sucroferric oxyhydroxide is an iron-based phosphate binder that can also provide some iron supplementation benefit.

(CSR) Board Certified Specialist in Renal Nutrition Practice Test