CSMLS CSMLS Immunology and Serology 2

Question 1

In a direct Coombs (DAT) test, a positive result indicates:

Accepted Answer

Antibodies or complement bound to red blood cells in vivo

Answer

A positive direct antiglobulin test (DAT) indicates that antibodies or complement proteins are already coating the patient's red blood cells in vivo.

Question 2

Rheumatoid factor (RF) is an autoantibody directed against:

Accepted Answer

The Fc portion of IgG

Answer

Rheumatoid factor is an autoantibody, typically IgM, that targets the Fc region of IgG immunoglobulins.

Question 3

Which antinuclear antibody (ANA) pattern is most associated with systemic lupus erythematosus (SLE)?

Accepted Answer

Homogeneous (diffuse)

Answer

The homogeneous (diffuse) ANA pattern is most commonly associated with SLE and correlates with anti-dsDNA and anti-histone antibodies.

Question 4

In a latex agglutination test, the latex particles are coated with:

Accepted Answer

Known antigen or antibody specific for the analyte being tested

Answer

Latex particles are coated with a known antigen or antibody so they agglutinate visibly when the complementary analyte is present in the patient sample.

Question 5

The VDRL and RPR tests are used to screen for:

Accepted Answer

Syphilis

Answer

The VDRL (Venereal Disease Research Laboratory) and RPR (Rapid Plasma Reagin) are non-treponemal screening tests for syphilis.

CSMLS - Canadian Society for Medical Laboratory Science Practice Test

CSMLS - Canadian Society for Medical Laboratory Science Practice Test

CSMLS CSMLS Immunology and Serology 2