CSMLS Hematology and Coagulation Questions and Answers

Question 1

A peripheral blood smear review is triggered by a 'Nucleated RBC' flag on an automated hematology analyzer.
The technologist counts 8 NRBCs per 100 WBCs.
The analyzer reported a total WBC count of 12.0 x 10^9/L.
What is the corrected WBC count?

Accepted Answer

11.1 x 10^9/L

Answer

12.0 x 10^9/L

Answer

13.0 x 10^9/L

Answer

11.5 x 10^9/L

Question 2

A patient presents with a microcytic anemia. The CBC results are as follows: HGB 105 g/L, MCV 65 fL, RBC 5.5 x 10^12/L, RDW 14.0%. Serum ferritin is normal. Which of the following conditions is most likely?

Accepted Answer

Beta-thalassemia trait

Answer

Anemia of chronic disease

Answer

Iron deficiency anemia

Answer

Sideroblastic anemia

Question 3

A patient has a prolonged activated partial thromboplastin time (APTT). A 1:1 mixing study is performed. The immediate APTT on the mix corrects into the normal range, but after a 2-hour incubation at 37°C, the APTT of the mixture becomes prolonged again. This pattern is most characteristic of:

Accepted Answer

A time- and temperature-dependent inhibitor, such as anti-Factor VIII

Answer

Factor V deficiency

Answer

Lupus anticoagulant

Answer

Heparin contamination

Question 4

The presence of Auer rods within blasts on a peripheral blood smear is most strongly associated with which of the following conditions?

Accepted Answer

Acute Myeloid Leukemia (AML)

Answer

Acute Lymphoblastic Leukemia (ALL)

Answer

Chronic Myeloid Leukemia (CML)

Answer

Chronic Lymphocytic Leukemia (CLL)

Question 5

A patient's sample run on a hematology analyzer at room temperature (22°C) produces an MCHC of 390 g/L and a very low RBC count. A peripheral smear shows large, irregular clumps of red blood cells. What is the most appropriate next step to obtain accurate CBC results?

Accepted Answer

Warm the sample to 37°C for 15-30 minutes and rerun

Answer

Request a new sample drawn in a sodium citrate tube

Answer

Perform a saline replacement procedure to correct for lipemia

Answer

Report the results with a comment about RBC agglutination

Question 6

A physician is evaluating a patient with a low pre-test probability for venous thromboembolism (VTE). Which of the following laboratory tests is most useful for ruling out this condition?

Accepted Answer

D-dimer

Answer

Prothrombin Time (PT)

Answer

Platelet Count

Answer

Fibrinogen Level

A peripheral blood smear review is triggered by a 'Nucleated RBC' flag on an automated hematology analyzer.The technologist counts 8 NRBCs per 100 WBCs.The analyzer reported a total WBC count of 12.0 x 10^9/L.What is the corrected WBC count?

A peripheral blood smear review is triggered by a 'Nucleated RBC' flag on an automated hematology analyzer.
The technologist counts 8 NRBCs per 100 WBCs.
The analyzer reported a total WBC count of 12.0 x 10^9/L.
What is the corrected WBC count?