CSMLS Transfusion Science Principles Questions and Answers

Question 1

An ABO discrepancy is observed in a 75-year-old patient.
The forward grouping shows Anti-A: 4+, Anti-B: 0.
The reverse grouping shows A1 cells: 0, B cells: 1+.
An autocontrol is negative.
What is the most probable cause of this discrepancy?

Accepted Answer

Age-related decrease in anti-B antibody production

Answer

A subgroup of A

Answer

Presence of a cold autoantibody

Answer

Rouleaux formation due to high protein levels

Question 2

A bone marrow transplant recipient requires a red blood cell transfusion. To prevent Transfusion-Associated Graft-Versus-Host Disease (TA-GVHD), which of the following component modifications is most critical?

Accepted Answer

Irradiated

Answer

Washed

Answer

CMV Seronegative

Answer

Leukoreduced

Question 3

Fifteen minutes into a red blood cell transfusion, a patient develops fever, chills, hypotension, and reports red-coloured urine. The post-transfusion direct antiglobulin test (DAT) is positive. What is the most likely type of transfusion reaction?

Accepted Answer

Acute Hemolytic Transfusion Reaction (AHTR)

Answer

Febrile Non-Hemolytic Reaction

Answer

Anaphylactic Reaction

Answer

Bacterial Contamination

Question 4

An RhD-negative mother has just delivered an RhD-positive infant. The mother's antibody screen is negative. According to Canadian guidelines, what is the primary purpose of administering Rh Immune Globulin (RhIG) to the mother within 72 hours?

Accepted Answer

To prevent the mother from forming anti-D that could affect future RhD-positive pregnancies

Answer

To treat any potential hemolytic disease in the current newborn

Answer

To suppress the mother's existing anti-D antibodies

Answer

To clear passive anti-D from a previous antenatal injection

Question 5

A patient has a history of a clinically significant antibody, anti-K, but their current antibody screen is negative. Which of the following is the most appropriate crossmatch procedure to ensure safety?

Accepted Answer

A full antiglobulin (IAT) crossmatch using K-antigen negative donor units.

Answer

Electronic crossmatch is acceptable because the current antibody screen is negative.

Answer

An immediate spin crossmatch to confirm ABO compatibility is sufficient.

Answer

No crossmatch is needed if O Negative units are provided.

Question 6

According to Canadian Standards Association (CSA) Z902 standards, what is the correct storage temperature range for Platelet concentrates?

Accepted Answer

20 to 24°C

Answer

1 to 6°C

Answer

-18°C or colder

Answer

37 ± 1°C

An ABO discrepancy is observed in a 75-year-old patient.The forward grouping shows Anti-A: 4+, Anti-B: 0.The reverse grouping shows A1 cells: 0, B cells: 1+.An autocontrol is negative.What is the most probable cause of this discrepancy?

An ABO discrepancy is observed in a 75-year-old patient.
The forward grouping shows Anti-A: 4+, Anti-B: 0.
The reverse grouping shows A1 cells: 0, B cells: 1+.
An autocontrol is negative.
What is the most probable cause of this discrepancy?