A 16-year-old presents with open and closed comedones, papules, and pustules on the face. Which mechanism is most responsible for the pathogenesis of acne vulgaris?
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A
Autoimmune destruction of sebaceous glands
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B
Follicular plugging with keratin and sebum combined with Cutibacterium acnes proliferation
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C
Staphylococcus aureus superficial skin infection
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D
IgE-mediated mast cell degranulation in the dermis