COKO Pharmacology Fundamentals 2

Question 1

A kinesiologist notices a client taking a beta-blocker reports an unusually low resting heart rate. Which pharmacodynamic concept explains this effect?

Accepted Answer

Antagonism at beta-adrenergic receptors

Answer

Beta-blockers act as antagonists at beta-adrenergic receptors, reducing heart rate by blocking sympathetic stimulation.

Question 2

Which term describes the concentration of a drug required to produce 50% of its maximum possible effect?

Accepted Answer

EC50

Answer

EC50 (effective concentration 50%) is the drug concentration producing half of the maximal response.

Question 3

A client on warfarin begins taking a new NSAID. The kinesiologist should be aware that this combination may increase risk of:

Accepted Answer

Bleeding

Answer

NSAIDs can displace warfarin from plasma proteins and inhibit platelet aggregation, significantly increasing bleeding risk.

Question 4

Which phase of pharmacokinetics involves the conversion of a drug to more water-soluble metabolites primarily in the liver?

Accepted Answer

Metabolism

Answer

Metabolism (biotransformation), mainly hepatic, converts lipophilic drugs into more polar metabolites for easier elimination.

Question 5

A client using a corticosteroid inhaler for asthma asks about systemic side effects. Which effect is most relevant for exercise programming?

Accepted Answer

Muscle weakness and reduced bone density

Answer

Long-term corticosteroid use can cause myopathy and osteoporosis, directly affecting exercise capacity and fracture risk.

(COKO) College of Kinesiologists of Ontario Practice Test

(COKO) College of Kinesiologists of Ontario Practice Test

COKO Pharmacology Fundamentals 2