CLT Food Sensitivities & Immunology Basics 2

Question 1

Which immune cell is the primary effector in IgE-mediated food allergy reactions and releases histamine upon antigen binding?

Accepted Answer

Mast cell

Answer

Mast cells bound with IgE antibodies degranulate and release histamine and other mediators when cross-linked by food allergens.

Question 2

In the LEAP protocol, the MRT blood test measures the change in which cellular parameter to identify reactive foods?

Accepted Answer

White blood cell and platelet volume after incubation

Answer

MRT quantifies the shift in white blood cell and platelet volume when blood is incubated with food antigens, reflecting mediator release.

Question 3

Which class of hypersensitivity reaction is NOT mediated by antibodies and instead relies on sensitized T lymphocytes?

Accepted Answer

Type IV (delayed)

Answer

Type IV hypersensitivity is cell-mediated, involving T lymphocytes rather than antibodies, and reactions appear 24–72 hours after exposure.

Question 4

Secretory IgA (sIgA) in the gut serves as the first line of adaptive immune defense primarily by:

Accepted Answer

Neutralizing antigens in the gut lumen before mucosal penetration

Answer

Secretory IgA coats food antigens and pathogens in the intestinal lumen, preventing them from binding to and crossing the mucosal epithelium.

Question 5

A patient with increased intestinal permeability ('leaky gut') is at greater risk for food sensitivities because:

Accepted Answer

Undigested food peptides cross the epithelium and trigger immune responses

Answer

Tight junction dysfunction allows large, undigested food peptides to enter the lamina propria, where they are recognized as foreign antigens and drive immune sensitization.

(CLT) Certified Leap Therapist Practice Test

(CLT) Certified Leap Therapist Practice Test

CLT Food Sensitivities & Immunology Basics 2