CIH Toxicology and Chemical Hazards 2

Question 1

Which toxicokinetic process describes the movement of a chemical from the bloodstream into tissues and organs?

Accepted Answer

Distribution

Answer

Distribution is the process by which a chemical moves from systemic circulation into tissues and organs throughout the body.

Question 2

A worker is exposed to a chemical with a high octanol-water partition coefficient (Kow). This suggests the chemical is likely to:

Accepted Answer

Bioaccumulate in adipose tissue

Answer

A high Kow indicates strong lipophilicity, meaning the chemical will preferentially partition into fat tissue and bioaccumulate.

Question 3

The Haber's Rule states that toxic effect is proportional to:

Accepted Answer

The concentration multiplied by duration of exposure

Answer

Haber's Rule (C × t = k) states that the toxic effect is the product of concentration and time of exposure.

Question 4

Which phase of biotransformation typically involves conjugation reactions that increase water solubility for excretion?

Accepted Answer

Phase II

Answer

Phase II biotransformation involves conjugation reactions (glucuronidation, sulfation, etc.) that add polar groups to increase water solubility.

Question 5

A chemical that causes damage specifically to the proximal convoluted tubule of the kidney is classified as a:

Accepted Answer

Nephrotoxin

Answer

Nephrotoxins cause damage to kidney structures, including specific regions like the proximal convoluted tubule.

CIH - Certified Industrial Hygienist Exam Practice Test