What is the primary mechanism by which asbestos fibers cause mesothelioma?
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A
Long, thin, biopersistent fibers penetrate the pleura and cause chronic inflammation and DNA damage
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B
Fibers dissolve in lung fluid releasing iron that generates free radicals only in the bronchi
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C
Asbestos fibers act as a chemical carcinogen through metabolic activation in the liver
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D
Short fibers are phagocytized and cleared, while only soluble fibers reach the pleura