CCTC Transplantation Management 3

Question 1

During evaluation of a potential living kidney donor, which finding would most likely disqualify donation?

Accepted Answer

GFR of 55 mL/min/1.73m²

Answer

A GFR below 60 mL/min/1.73m² in a potential living donor indicates insufficient renal reserve to safely donate one kidney.

Question 2

What is the primary purpose of induction immunosuppression therapy in transplantation?

Accepted Answer

To provide intense immunosuppression at the time of highest rejection risk around the transplant surgery

Answer

Induction therapy provides high-intensity immunosuppression during the peritransplant period when alloreactivity is greatest.

Question 3

A heart transplant recipient's endomyocardial biopsy shows grade 2R (moderate) acute cellular rejection without hemodynamic compromise. What is the standard treatment?

Accepted Answer

High-dose pulse corticosteroids

Answer

Grade 2R rejection is typically treated with high-dose pulse IV methylprednisolone followed by an oral steroid taper.

Question 4

Which serology result pattern in a transplant candidate indicates immunity to hepatitis B virus through prior vaccination?

Accepted Answer

HBsAg negative, anti-HBc negative, anti-HBs positive

Answer

Vaccination-induced immunity produces anti-HBs antibodies alone, without anti-HBc, because the vaccine contains only surface antigen.

Question 5

Which organ demonstrates the highest five-year graft survival rate in solid organ transplantation?

Accepted Answer

Kidney

Answer

Kidney transplantation has the highest five-year graft survival rate among solid organs, exceeding 85% for living donor transplants.

CCTC - Certified Clinical Transplant Coordinator Practice Test

CCTC - Certified Clinical Transplant Coordinator Practice Test

CCTC Transplantation Management 3