CCTC - Certified Clinical Transplant Coordinator Organ-Specific Transplant Knowledge Questions and Answers

Question 1

A patient who received a simultaneous pancreas-kidney (SPK) transplant 48 hours ago develops sudden hyperglycemia and requires an insulin infusion.
What is the most likely cause of this early pancreas allograft dysfunction?

Accepted Answer

Venous thrombosis of the graft

Answer

Hyperacute rejection

Answer

Graft pancreatitis

Answer

Cytomegalovirus (CMV) infection

Question 2

Which of the following laboratory values is a component of the Model for End-Stage Liver Disease-Sodium (MELD-Na) score used for adult liver allocation?

Accepted Answer

Total Bilirubin

Answer

Serum Albumin

Answer

Aspartate aminotransferase (AST)

Answer

Prothrombin Time (PT)

Question 3

According to long-term outcome data, which of the following is a leading cause of mortality in heart transplant recipients AFTER the first year post-transplant?

Accepted Answer

Cardiac Allograft Vasculopathy (CAV)

Answer

Primary graft dysfunction

Answer

Acute cellular rejection

Answer

Bacterial pneumonia

Question 4

A transplant coordinator is reviewing data for a patient with idiopathic pulmonary fibrosis being evaluated for the lung transplant waitlist. Which of the following factors will contribute MOST significantly to increasing the patient's Lung Allocation Score (LAS) or Composite Allocation Score (CAS)?

Accepted Answer

The requirement for 6 L/min of continuous supplemental oxygen at rest

Answer

A six-minute walk distance of 350 meters

Answer

A serum creatinine of 1.0 mg/dL

Answer

A diagnosis of well-controlled type 2 diabetes

Question 5

A kidney transplant recipient's biopsy confirms acute antibody-mediated rejection (AMR) with C4d staining and circulating donor-specific antibodies (DSAs). In addition to optimizing maintenance immunosuppression, which therapy is specifically aimed at the physical removal of the pathogenic circulating antibodies?

Accepted Answer

Plasmapheresis (Plasma Exchange)

Answer

High-dose intravenous corticosteroids

Answer

Antithymocyte globulin (ATG)

Answer

Rituximab

Question 6

A transplant coordinator is evaluating a patient for an intestinal transplant. Which of the following is considered a primary indication for transplantation due to a life-threatening complication of total parenteral nutrition (TPN)?

Accepted Answer

Development of TPN-associated progressive liver disease (PNALD)

Answer

Patient preference to resume an oral diet

Answer

A single episode of catheter-related line sepsis

Answer

Frequent high stoma output requiring IV fluid replacement

A patient who received a simultaneous pancreas-kidney (SPK) transplant 48 hours ago develops sudden hyperglycemia and requires an insulin infusion.What is the most likely cause of this early pancreas allograft dysfunction?

A patient who received a simultaneous pancreas-kidney (SPK) transplant 48 hours ago develops sudden hyperglycemia and requires an insulin infusion.
What is the most likely cause of this early pancreas allograft dysfunction?