A patient taking warfarin is prescribed trimethoprim-sulfamethoxazole (TMP-SMX) for a UTI. What is the key concern?
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A
TMP-SMX reduces warfarin absorption
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B
TMP-SMX inhibits CYP2C9, raising INR and increasing bleeding risk
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C
TMP-SMX has no interaction with warfarin
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D
TMP-SMX decreases anticoagulation effect of warfarin