SPEX SPEX Assessment Exam 4

Question 1

Which pharmacokinetic parameter describes the fraction of an administered dose that reaches systemic circulation unchanged?

Accepted Answer

Bioavailability

Answer

Bioavailability (F) represents the proportion of administered drug that reaches systemic circulation in active form.

Question 2

A patient taking phenytoin develops nausea, diplopia, and ataxia. These symptoms are most consistent with:

Accepted Answer

Phenytoin toxicity due to elevated serum levels

Answer

Nausea, diplopia, and ataxia are classic signs of phenytoin toxicity, typically occurring at serum levels above 20 mcg/mL.

Question 3

Which medication requires a Risk Evaluation and Mitigation Strategy (REMS) program due to risks of severe birth defects?

Accepted Answer

Isotretinoin

Answer

Isotretinoin (iPLEDGE REMS) requires strict pregnancy prevention measures due to its extreme teratogenicity.

Question 4

What is the primary reason insulin glargine should NOT be mixed with other insulins in the same syringe?

Accepted Answer

Mixing alters its pH and destroys its prolonged-action formulation

Answer

Glargine's extended action depends on its acidic pH (4.0), which is disrupted by mixing, eliminating its long-acting profile.

Question 5

A pharmacy technician accepts a faxed prescription for a Schedule II controlled substance. What is the pharmacist's appropriate response?

Accepted Answer

Inform the technician that Schedule II drugs require an original written or electronic prescription, with limited emergency exceptions

Answer

Federal law requires Schedule II controlled substances to be dispensed only with an original written or valid electronic prescription; faxes serve only as a record with limited emergency exceptions.

SPEX Exam Practice Test

SPEX Exam Practice Test

SPEX SPEX Assessment Exam 4