SPEX SPEX Assessment Exam 2

Question 1

A patient on warfarin is prescribed trimethoprim-sulfamethoxazole for a UTI. What is the most likely drug interaction concern?

Accepted Answer

Enhanced anticoagulant effect leading to bleeding risk

Answer

TMP-SMX inhibits CYP2C9, the primary enzyme metabolizing warfarin, increasing warfarin levels and bleeding risk.

Question 2

Which controlled substance schedule includes drugs with accepted medical use but the highest abuse potential?

Accepted Answer

Schedule II

Answer

Schedule II drugs have accepted medical use but carry the highest abuse potential among approved medications.

Question 3

A patient with CrCl of 30 mL/min is prescribed metformin. What is the most appropriate pharmacist action?

Accepted Answer

Contact the prescriber to discuss discontinuation or alternative

Answer

Metformin is contraindicated when CrCl is below 30 mL/min due to risk of lactic acidosis.

Question 4

Which statement about the Orange Book is most accurate?

Accepted Answer

It identifies drug products with established patent and exclusivity information and therapeutic equivalence ratings

Answer

The FDA's Orange Book (Approved Drug Products with Therapeutic Equivalence Evaluations) lists therapeutic equivalence ratings and patent/exclusivity data.

Question 5

A child weighing 22 kg needs amoxicillin for otitis media. The standard pediatric dose is 90 mg/kg/day in 2 divided doses. What is the correct dose per administration?

Accepted Answer

990 mg

Answer

90 mg/kg/day × 22 kg = 1980 mg/day ÷ 2 doses = 990 mg per dose.

SPEX Exam Practice Test

SPEX Exam Practice Test

SPEX SPEX Assessment Exam 2