SPEX Dermatology 5

Question 1

A 45-year-old woman presents with target-like lesions on her palms and oral erosions after starting trimethoprim-sulfamethoxazole. What is the most likely diagnosis?

Accepted Answer

Erythema multiforme major (Stevens-Johnson syndrome)

Answer

Stevens-Johnson syndrome (erythema multiforme major) is characterized by target lesions, mucosal erosions, and is commonly triggered by sulfonamides.

Question 2

Which feature distinguishes a melanoma from a benign melanocytic nevus using the ABCDE criteria?

Accepted Answer

Border irregularity

Answer

Border irregularity (notched, scalloped, or ill-defined edges) is a key ABCDE criterion distinguishing melanoma from benign nevi.

Question 3

A newborn has vesicles grouped in a dermatomal pattern on the trunk. Tzanck smear shows multinucleated giant cells. What is the most appropriate treatment?

Accepted Answer

IV acyclovir

Answer

Neonatal herpes simplex virus infection is a medical emergency requiring immediate IV acyclovir due to the risk of dissemination and mortality.

Question 4

A patient presents with comedones, inflammatory papules, and nodules on the face and back. Which topical agent works by normalizing follicular keratinization and is considered a first-line treatment for acne?

Accepted Answer

Topical retinoids (tretinoin)

Answer

Topical retinoids normalize follicular keratinization, prevent microcomedo formation, and are considered the backbone of topical acne therapy.

Question 5

Which HLA type is strongly associated with psoriasis and psoriatic arthritis?

Accepted Answer

HLA-Cw6

Answer

HLA-Cw6 (now designated HLA-C*06:02) is the major genetic risk factor for psoriasis vulgaris and psoriatic arthritis.

SPEX Exam Practice Test

SPEX Exam Practice Test

SPEX Dermatology 5