Saudi Prometric Pharmacist Sterile Products and Aseptic Techniques 2

Question 1

What is the key difference between a Biological Safety Cabinet (BSC) and a Laminar Airflow Workbench (LAFW)?

Accepted Answer

A BSC protects the operator from hazardous drug exposure; a LAFW does not

Answer

A BSC protects both the sterile product and the operator/environment from hazardous drug aerosols by exhausting HEPA-filtered air away from the operator, while a LAFW only protects the product.

Question 2

What is the correct sequence for donning personal protective equipment (PPE) when entering a cleanroom?

Accepted Answer

Shoe covers → head cover → mask → gown → gloves

Answer

Garbing proceeds from the floor upward — shoe covers first, then head cover, mask, gown — with gloves donned last, just before beginning aseptic work to minimize contamination of the hands.

Question 3

What is the primary purpose of environmental monitoring in a pharmacy cleanroom?

Accepted Answer

To verify ongoing microbiological quality of the compounding environment

Answer

Environmental monitoring — both viable (microbial) and non-viable (particle) sampling — verifies that the cleanroom maintains microbiological quality necessary to produce sterile preparations consistently.

Question 4

Why is pyrogen (endotoxin) testing important for parenteral preparations?

Accepted Answer

To detect bacterial cell wall components that cause fever and septic shock

Answer

Endotoxins are heat-stable lipopolysaccharide fragments from gram-negative bacterial cell walls that cause fever and septic shock; they persist even after sterilization kills all bacteria.

Question 5

Which intravenous solution is considered isotonic with human plasma?

Accepted Answer

0.9% sodium chloride (normal saline)

Answer

0.9% sodium chloride has an osmolality of approximately 308 mOsm/kg, matching plasma osmolality and preventing red blood cell lysis or crenation upon intravenous administration.

Saudi Prometric Pharmacist Practice Test

Saudi Prometric Pharmacist Practice Test

Saudi Prometric Pharmacist Sterile Products and Aseptic Techniques 2