Saudi Prometric Pharmacist Pharmacology and Therapeutics

Question 1

What is the mechanism of action of omeprazole (proton pump inhibitor)?

Accepted Answer

Irreversibly inhibits the H+/K+ ATPase enzyme system (proton pump) in gastric parietal cells

Answer

Blocks histamine H2 receptors

Answer

Neutralizes stomach acid directly

Answer

Stimulates bicarbonate secretion

Question 2

Which antihypertensive class is contraindicated in pregnancy?

Accepted Answer

ACE inhibitors and ARBs

Answer

Calcium channel blockers

Answer

Methyldopa

Answer

Labetalol

Question 3

What is the primary concern when dispensing methotrexate for a patient?

Accepted Answer

Ensure correct dosing frequency (usually weekly, NOT daily for autoimmune conditions), and verify hepatic/renal function and CBC

Answer

It causes weight gain

Answer

It has no significant side effects

Answer

It should be taken with dairy products

Question 4

What is the clinical significance of the CYP3A4 enzyme system in drug interactions?

Accepted Answer

CYP3A4 metabolizes approximately 50% of all drugs, so inhibitors and inducers significantly alter drug levels

Answer

It has no clinical significance

Answer

It only affects antibiotics

Answer

It only works in the kidneys

Question 5

What monitoring is required for a patient starting statin therapy?

Accepted Answer

Baseline and periodic liver function tests (ALT), lipid profile, and assessment for myopathy symptoms (muscle pain/weakness)

Answer

Only cholesterol levels

Answer

Blood pressure only

Answer

No monitoring needed

Question 6

What is the appropriate first-line treatment for community-acquired pneumonia in an otherwise healthy adult in Saudi Arabia?

Accepted Answer

Oral amoxicillin or a macrolide (azithromycin) for outpatient treatment

Answer

IV vancomycin

Answer

IV meropenem

Answer

Oral metronidazole