PTCB Pharmacology #1 3

Question 1

Which enzyme does warfarin inhibit to produce its anticoagulant effect?

Accepted Answer

Vitamin K epoxide reductase

Answer

Thrombin directly

Answer

Factor Xa directly

Answer

Plasminogen activator

Question 2

Statins reduce LDL cholesterol primarily by:

Accepted Answer

Inhibiting HMG-CoA reductase in the liver

Answer

Binding bile acids in the gut

Answer

Blocking intestinal cholesterol absorption

Answer

Activating lipoprotein lipase

Question 3

A drug with a narrow therapeutic index (NTI) is best described as:

Accepted Answer

A drug where there is little difference between the effective and toxic dose

Answer

A drug that is only effective at very high doses

Answer

A drug with minimal side effects

Answer

A drug that is available in only one dosage form

Question 4

Omeprazole (Prilosec) is an example of which type of drug?

Accepted Answer

Proton pump inhibitor

Answer

H2 receptor antagonist

Answer

Antacid

Answer

Sucralfate

Question 5

Which of the following neurotransmitters is primarily affected by SSRI antidepressants?

Accepted Answer

Serotonin

Answer

Dopamine

Answer

GABA

Answer

Norepinephrine

Question 6

What is a prodrug?

Accepted Answer

A drug administered in an inactive form that is converted to the active form in the body

Answer

A drug that bypasses hepatic metabolism entirely

Answer

A drug with no therapeutic effect until combined with another drug

Answer

The first drug discovered in a pharmacological class