Pharmacy Therapeutics 3

Question 1

A patient with COPD and chronic stable angina needs a beta-blocker. Which agent is most appropriate?

Accepted Answer

Metoprolol succinate

Answer

Metoprolol succinate is a cardioselective beta-1 blocker that minimizes bronchoconstriction risk compared to non-selective agents in patients with COPD.

Question 2

Clindamycin is used to treat infections caused by which of the following organisms?

Accepted Answer

Methicillin-resistant Staphylococcus aureus (MRSA)

Answer

Clindamycin has activity against MRSA in skin and soft tissue infections and also provides anaerobic coverage.

Question 3

Which disease-modifying antirheumatic drug (DMARD) requires baseline and periodic ophthalmology exams due to risk of retinal toxicity?

Accepted Answer

Hydroxychloroquine

Answer

Hydroxychloroquine can deposit in the retina causing irreversible macular toxicity, so annual ophthalmologic exams are mandatory.

Question 4

A patient presents with opioid overdose. Which reversal agent is administered, and what is its mechanism?

Accepted Answer

Naloxone — opioid receptor antagonist

Answer

Naloxone competitively antagonizes mu, kappa, and delta opioid receptors, rapidly reversing respiratory depression caused by opioid overdose.

Question 5

A patient with major depressive disorder fails two adequate SSRI trials. What is the most appropriate next step according to treatment guidelines?

Accepted Answer

Switch to an SNRI or add augmentation with atypical antipsychotic

Answer

After failure of two SSRIs, switching to an SNRI or augmenting with bupropion, atypical antipsychotics, or lithium is guideline-recommended before escalating to ECT.

Pharmacy Practice Test

Pharmacy Practice Test

Pharmacy Therapeutics 3