AMC MCQ AMC MCQ - Australian Medical Council Multiple Choice Questions Infectious Diseases and Immunology Questions and Answers 2

Question 1

A 60-year-old renal transplant recipient presents with fever and a rising serum creatinine 3 months post-transplant. CMV antigenemia assay is positive. What is the treatment of choice?

Accepted Answer

Ganciclovir (IV) or valganciclovir (oral)

Answer

Ganciclovir IV or oral valganciclovir is the first-line treatment for CMV disease in transplant recipients.

Question 2

A 25-year-old presents with fever, sore throat, lymphadenopathy, and a positive heterophile antibody (Monospot) test. Which virus is responsible?

Accepted Answer

Epstein-Barr virus

Answer

Epstein-Barr virus causes infectious mononucleosis, characterized by the triad of fever, pharyngitis, and lymphadenopathy with a positive Monospot test.

Question 3

Which immunoglobulin class is primarily responsible for the secondary (anamnestic) immune response?

Accepted Answer

IgG

Answer

IgG is the predominant antibody of the secondary immune response, providing long-lasting humoral immunity.

Question 4

A healthcare worker is exposed to a needlestick from an HBeAg-positive patient. The worker is unvaccinated. What is the most appropriate immediate management?

Accepted Answer

Hepatitis B immune globulin (HBIG) plus hepatitis B vaccination

Answer

Post-exposure prophylaxis for hepatitis B in unvaccinated individuals requires both HBIG (immediate passive immunity) and hepatitis B vaccine.

Question 5

Deficiency of which complement protein predisposes to recurrent Neisseria infections?

Accepted Answer

C5–C9 (terminal complement)

Answer

Deficiency of terminal complement components (C5–C9, the membrane attack complex) impairs killing of Neisseria species, predisposing to recurrent meningococcal and gonococcal infections.

AMC MCQ Practice Test

AMC MCQ Practice Test

AMC MCQ AMC MCQ - Australian Medical Council Multiple Choice Questions Infectious Diseases and Immunology Questions and Answers 2