AMC MCQ AMC MCQ - Australian Medical Council Multiple Choice Questions Haematology and Oncology Questions and Answers

Question 1

A 70-year-old presents with fatigue, bone pain, hypercalcaemia, and serum protein electrophoresis showing an M-spike. Bone marrow biopsy shows 30% plasma cells. What is the diagnosis?

Accepted Answer

Multiple myeloma

Answer

Multiple myeloma is defined by >10% clonal plasma cells in bone marrow plus end-organ damage (hypercalcaemia, renal failure, anaemia, or bone lesions — CRAB criteria).

Question 2

A 25-year-old presents with painless cervical lymphadenopathy, fever, night sweats, and weight loss. Biopsy shows Reed-Sternberg cells. What is the most likely diagnosis?

Accepted Answer

Hodgkin lymphoma

Answer

Reed-Sternberg cells are pathognomonic of Hodgkin lymphoma, which typically presents with B symptoms and mediastinal or cervical lymphadenopathy.

Question 3

A patient with chronic myeloid leukaemia (CML) is found to have the Philadelphia chromosome t(9;22). Which molecular target does imatinib inhibit?

Accepted Answer

BCR-ABL tyrosine kinase

Answer

Imatinib is a selective BCR-ABL tyrosine kinase inhibitor that blocks the constitutively active kinase produced by the Philadelphia chromosome translocation in CML.

Question 4

A 60-year-old patient on warfarin presents with an INR of 8.5 and minor bleeding. What is the most appropriate management?

Accepted Answer

Hold warfarin and administer oral vitamin K 1–2.5 mg

Answer

For elevated INR with minor bleeding, withholding warfarin and giving low-dose oral vitamin K (1–2.5 mg) is appropriate to reverse anticoagulation safely.

Question 5

A 45-year-old woman has a microcytic, hypochromic anaemia with serum ferritin of 5 µg/L and low serum iron. What is the most likely cause?

Accepted Answer

Iron deficiency anaemia

Answer

Low ferritin combined with microcytic hypochromic anaemia and low serum iron is diagnostic of iron deficiency anaemia.

AMC MCQ Practice Test

AMC MCQ Practice Test

AMC MCQ AMC MCQ - Australian Medical Council Multiple Choice Questions Haematology and Oncology Questions and Answers