ONCC ONCC Hematologic Malignancies 2

Question 1

A patient undergoing induction chemotherapy for acute lymphoblastic leukemia (ALL) develops tumor lysis syndrome. Which electrolyte abnormality combination is expected?

Accepted Answer

Hyperkalemia, hyperphosphatemia, hypocalcemia, and elevated uric acid

Answer

Tumor lysis syndrome causes hyperkalemia, hyperphosphatemia, hypocalcemia (from phosphate binding), and hyperuricemia as massive cell death releases intracellular contents.

Question 2

Which intervention is the cornerstone of tumor lysis syndrome prevention in high-risk hematologic malignancies?

Accepted Answer

Aggressive IV hydration and allopurinol or rasburicase administration

Answer

Vigorous IV hydration promotes renal uric acid and phosphate excretion, while allopurinol or rasburicase reduces uric acid production or degradation, preventing TLS.

Question 3

A patient with multiple myeloma is started on bortezomib. The nurse should educate the patient about which commonly expected side effect?

Accepted Answer

Peripheral neuropathy, fatigue, and thrombocytopenia

Answer

Bortezomib (a proteasome inhibitor) commonly causes peripheral neuropathy, fatigue, thrombocytopenia, and GI side effects, which patients must be educated to recognize and report.

Question 4

The Ann Arbor staging system is used for which malignancies?

Accepted Answer

Hodgkin and non-Hodgkin lymphoma

Answer

The Ann Arbor staging system classifies Hodgkin and non-Hodgkin lymphoma by the number and location of lymph node regions involved and presence of extranodal disease.

Question 5

Which finding is most consistent with neutropenic fever in a patient with hematologic malignancy receiving chemotherapy?

Accepted Answer

Single oral temperature ≥38.3°C (101°F) or ≥38°C (100.4°F) sustained, with ANC <500/µL

Answer

Neutropenic fever is defined as a single temperature ≥38.3°C or sustained ≥38°C with ANC <500/µL (or expected to fall below 500), requiring immediate broad-spectrum antibiotics.

ONCC - Oncology Nursing Certification Corporation Practice Test

ONCC - Oncology Nursing Certification Corporation Practice Test

ONCC ONCC Hematologic Malignancies 2