ONCC Chemotherapy Administration and Safety

Question 1

When administering a vesicant chemotherapy agent via peripheral IV, how often should the nurse assess the site for signs of extravasation?

Accepted Answer

Every 30 minutes during infusion

Answer

Every 4 hours

Answer

Every 1-2 hours

Answer

Before and after each shift

Question 2

A nurse is preparing to administer doxorubicin. Which piece of personal protective equipment (PPE) is MOST essential according to NIOSH hazardous drug handling guidelines?

Accepted Answer

Double chemotherapy-rated gloves and a closed-front gown

Answer

Surgical mask only

Answer

Single nitrile gloves

Answer

Standard latex gloves and paper gown

Question 3

Which action is the FIRST priority when a chemotherapy extravasation is suspected?

Accepted Answer

Stop the infusion immediately and disconnect the IV tubing

Answer

Apply a warm compress to the site

Answer

Notify the physician

Answer

Administer the antidote subcutaneously

Question 4

A patient is ordered paclitaxel. Before administration, the nurse should premedicate with which combination to prevent hypersensitivity reactions?

Accepted Answer

Dexamethasone, diphenhydramine, and an H2 blocker

Answer

Ondansetron, lorazepam, and haloperidol

Answer

Prednisone, acetaminophen, and famotidine

Answer

Methylprednisolone and epinephrine

Question 5

Which of the following is the correct approach for handling a chemotherapy spill on the floor?

Accepted Answer

Don PPE, use a spill kit, clean from the outside in, and dispose in a yellow hazardous waste container

Answer

Use paper towels to absorb the spill, then dispose in regular trash

Answer

Call environmental services immediately and leave the area

Answer

Dilute with large amounts of water and mop up

Question 6

The nurse is administering rituximab and the patient develops chills, fever, hypotension, and bronchospasm 30 minutes into the infusion. What is the MOST likely cause?

Accepted Answer

Cytokine release syndrome

Answer

Extravasation

Answer

Tumor lysis syndrome

Answer

Anaphylaxis from the IV fluid

Question 7

When checking a chemotherapy order for safety, which verification is MOST critical before administration?

Accepted Answer

Verifying dose per body surface area or weight against the prescribed protocol

Answer

Confirming the patient's room number

Answer

Checking the IV line label only

Answer

Confirming the infusion pump is the correct brand