OGT Medications and Factors Affecting OGTT Results 2

Question 1

Acute physiological stress such as surgery or serious infection affects OGTT reliability by:

Accepted Answer

Raising glucose via counter-regulatory hormone release

Answer

Stress triggers release of cortisol, epinephrine, glucagon, and growth hormone, all of which raise blood glucose — making OGTT during acute illness invalid.

Question 2

Which endocrine condition, if untreated, will predictably cause abnormal OGTT results due to excess growth hormone?

Accepted Answer

Acromegaly

Answer

Acromegaly (excess growth hormone) causes insulin resistance and impaired glucose tolerance, commonly revealed by OGTT.

Question 3

Hyperthyroidism affects OGTT interpretation because thyroid hormones:

Accepted Answer

Accelerate glucose absorption and increase hepatic glucose output, elevating post-load glucose

Answer

Excess thyroid hormones accelerate gastrointestinal glucose absorption and increase hepatic glucose output, causing an exaggerated early OGTT peak.

Question 4

Which factor associated with prolonged bed rest most significantly impairs OGTT results?

Accepted Answer

Skeletal muscle insulin resistance from physical inactivity

Answer

Physical inactivity from bed rest reduces GLUT4 expression and decreases insulin-stimulated glucose uptake in skeletal muscle, worsening insulin sensitivity.

Question 5

Alcohol consumption the night before an OGTT can cause:

Accepted Answer

Falsely low fasting glucose due to inhibition of hepatic gluconeogenesis

Answer

Alcohol inhibits hepatic gluconeogenesis, which can cause falsely low fasting glucose on an OGTT performed the morning after drinking.

OGT - Oral Glucose Tolerance Practice Test

OGT - Oral Glucose Tolerance Practice Test

OGT Medications and Factors Affecting OGTT Results 2