NAPLEX QBANK Sterile and Non-sterile Compounding 3

Question 1

A pharmacist must compound a 1:10,000 epinephrine solution. How many grams of epinephrine are in 500 mL of this solution?

Accepted Answer

0.05 g

Answer

A 1:10,000 ratio equals 1 g per 10,000 mL, so 500 mL contains 0.05 g.

Question 2

When preparing an admixture, what is 'coring' and how is it minimized?

Accepted Answer

Dislodging a rubber fragment into the vial; minimized by inserting the needle bevel up at an angle

Answer

Coring is a rubber-stopper fragment dislodged into the vial, reduced by inserting the needle bevel-up at a 45–60° angle and applying gentle pressure.

Question 3

What is the minimum percentage of active ingredient recovery typically required for an acceptable compounded preparation?

Accepted Answer

90–110% of labeled potency

Answer

Compounded preparations generally must contain 90–110% of the labeled amount of active ingredient.

Question 4

Geometric dilution is a technique used primarily to achieve what during non-sterile compounding?

Accepted Answer

Uniform mixing of a small amount of potent drug with a larger amount of diluent

Answer

Geometric dilution ensures uniform distribution of a small quantity of potent drug throughout a larger diluent base.

Question 5

How many milliliters of a 50% dextrose stock solution are needed to prepare 1,000 mL of a 10% dextrose solution?

Accepted Answer

200 mL

Answer

Using C1V1 = C2V2: (50%)(V1) = (10%)(1000 mL), so V1 = 200 mL.

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