FREE NAPLEX QBANK Therapeutic Treatment Planning Questions and Answers

Question 1

A 68-year-old male with a new diagnosis of heart failure with reduced ejection fraction (HFrEF) is being evaluated for initiation of guideline-directed medical therapy (GDMT).
His vital signs are stable, and he is euvolemic.
According to the 2024 ACC Expert Consensus Decision Pathway, which of the following represents the core foundational therapies that should be initiated?

Accepted Answer

An angiotensin receptor-neprilysin inhibitor (ARNI), an evidence-based beta-blocker, a mineralocorticoid receptor antagonist (MRA), and a sodium-glucose cotransporter-2 (SGLT2) inhibitor.

Answer

An ACE inhibitor, a beta-blocker, a loop diuretic, and an aldosterone antagonist.

Answer

An angiotensin receptor blocker (ARB), a beta-blocker, a thiazide diuretic, and digoxin.

Answer

A hydralazine/isosorbide dinitrate combination, a beta-blocker, a loop diuretic, and an SGLT2 inhibitor.

Question 2

A 55-year-old female is newly diagnosed with type 2 diabetes. Her initial A1C is 7.2%, and she has no history of atherosclerotic cardiovascular disease, heart failure, or chronic kidney disease. Which of the following is the most appropriate first-line pharmacologic agent to initiate in addition to lifestyle modifications?

Accepted Answer

Metformin

Answer

Glipizide

Answer

Empagliflozin

Answer

Insulin glargine

Question 3

A 45-year-old patient is initiated on lithium for the management of bipolar disorder. Which of the following sets of baseline laboratory tests is essential to obtain before starting therapy?

Accepted Answer

Serum creatinine (renal function), thyroid stimulating hormone (TSH), complete blood count (CBC), and a pregnancy test.

Answer

Liver function tests, lipid panel, and hemoglobin A1c.

Answer

Uric acid, serum iron, and vitamin B12 levels.

Answer

Chest X-ray, electrocardiogram (ECG), and serum magnesium.

Question 4

A 62-year-old male with a history of COPD and diabetes presents to an outpatient clinic with symptoms of community-acquired pneumonia (CAP). He has not been recently hospitalized or received IV antibiotics. According to the 2019 ATS/IDSA guidelines, which of the following is an appropriate empiric antibiotic regimen for this patient?

Accepted Answer

Amoxicillin/clavulanate 875 mg/125 mg twice daily PLUS doxycycline 100 mg twice daily

Answer

Amoxicillin 1 g three times daily

Answer

Azithromycin 500 mg daily

Answer

Ciprofloxacin 500 mg twice daily

Question 5

A 34-year-old patient is diagnosed with generalized anxiety disorder (GAD) and is seeking pharmacotherapy. The patient has no other medical conditions and takes no other medications. Which of the following medication classes is considered first-line treatment for this condition?

Accepted Answer

Selective Serotonin Reuptake Inhibitors (SSRIs)

Answer

Benzodiazepines

Answer

Tricyclic Antidepressants (TCAs)

Answer

Antipsychotics

Question 6

According to the 2017 ACC/AHA High Blood Pressure Clinical Practice Guideline, which of the following is the most appropriate first-line medication choice for a 58-year-old Black male newly diagnosed with Stage 1 hypertension and no other comorbidities?

Accepted Answer

Hydrochlorothiazide

Answer

Lisinopril

Answer

Atenolol

Answer

Losartan