NAPLEX QBANK Practice Test 2

Question 1

A patient on warfarin needs an antibiotic. Which choice carries the HIGHEST risk of increasing INR?

Accepted Answer

Trimethoprim-sulfamethoxazole

Answer

Trimethoprim-sulfamethoxazole inhibits CYP2C9 and displaces warfarin from protein, markedly raising INR.

Question 2

Which counseling point is essential for a patient starting alendronate?

Accepted Answer

Take with at least 6 oz water and remain upright 30 minutes

Answer

Bisphosphonates must be taken with plain water on an empty stomach, staying upright to prevent esophageal irritation.

Question 3

A patient with hyperkalemia (K 6.2) and ECG changes should first receive which agent to stabilize the myocardium?

Accepted Answer

Calcium gluconate

Answer

IV calcium gluconate stabilizes the cardiac membrane immediately, even though it does not lower potassium.

Question 4

Which statin requires the most caution when combined with gemfibrozil due to rhabdomyolysis risk?

Accepted Answer

Simvastatin

Answer

Gemfibrozil is contraindicated with simvastatin because it greatly increases statin exposure and myopathy risk.

Question 5

What is the antidote for acetaminophen overdose?

Accepted Answer

N-acetylcysteine

Answer

N-acetylcysteine replenishes glutathione to detoxify the toxic NAPQI metabolite.