MBBS Pharmacology 2

Question 1

Which of the following is the reversal agent for heparin toxicity?

Accepted Answer

Protamine sulfate

Answer

Protamine sulfate is a positively charged molecule that binds and neutralizes negatively charged heparin, reversing its anticoagulant effect.

Question 2

Which diuretic acts on the thick ascending limb of the loop of Henle?

Accepted Answer

Furosemide

Answer

Furosemide is a loop diuretic that inhibits the Na-K-2Cl cotransporter (NKCC2) in the thick ascending limb, producing potent diuresis.

Question 3

Which antimalarial drug can cause hemolytic anemia in patients with G6PD deficiency?

Accepted Answer

Primaquine

Answer

Primaquine generates reactive oxygen species that cause hemolysis in G6PD-deficient patients who cannot regenerate NADPH to protect red blood cells.

Question 4

Warfarin's anticoagulant effect is due to inhibition of which enzyme?

Accepted Answer

Vitamin K epoxide reductase

Answer

Warfarin inhibits vitamin K epoxide reductase, preventing regeneration of reduced vitamin K needed for carboxylation of clotting factors II, VII, IX, and X.

Question 5

Which drug class is used as first-line treatment for type 2 diabetes and acts by reducing hepatic glucose production?

Accepted Answer

Biguanides (Metformin)

Answer

Metformin (a biguanide) primarily reduces hepatic gluconeogenesis by activating AMPK and is first-line therapy for type 2 diabetes.

MBBS - Bachelor of Medicine and Bachelor of Surgery Practice Test

MBBS - Bachelor of Medicine and Bachelor of Surgery Practice Test

MBBS Pharmacology 2