IBD Knowledge 5

Question 1

Which of the following extraintestinal manifestations of IBD is classified as 'independent' of disease activity?

Accepted Answer

Primary sclerosing cholangitis

Answer

PSC runs an independent course from IBD activity, often progressing even after colectomy, unlike type 1 peripheral arthropathy which tracks with gut inflammation.

Question 2

What is the recommended first-line treatment for mild-to-moderate left-sided ulcerative colitis?

Accepted Answer

Topical (rectal) mesalamine suppositories or enemas combined with oral mesalamine

Answer

Combined topical and oral mesalamine is more effective than either alone and is the evidence-based first-line approach for left-sided UC.

Question 3

A patient with Crohn's disease develops a low-output enterocutaneous fistula after surgery. What is the initial management priority?

Accepted Answer

Optimization of nutrition, skin care, control of sepsis, and delineation of anatomy

Answer

The SNAP approach (Sepsis control, Nutrition, Anatomy definition, Procedure) guides initial fistula management before considering surgical or biologic intervention.

Question 4

In pediatric IBD, which pattern is more common compared to adult-onset IBD?

Accepted Answer

More extensive disease at diagnosis, including pancolitis in UC and upper GI involvement in Crohn's

Answer

Children with IBD typically present with more extensive disease; pediatric UC frequently involves the entire colon and pediatric Crohn's more often involves the upper GI tract.

Question 5

What is the role of fecal microbiota transplantation (FMT) in IBD as of current evidence?

Accepted Answer

Promising experimental therapy with evidence in UC but not yet standard of care

Answer

Multiple RCTs show FMT can induce remission in mild-to-moderate UC, but it lacks regulatory approval for IBD and is not yet standard of care.

IBD - Inflammatory Bowel Disease Practice Test

IBD - Inflammatory Bowel Disease Practice Test

IBD Knowledge 5