IBD Knowledge 2

Question 1

Which serological marker is most strongly associated with Crohn's disease?

Accepted Answer

ASCA (anti-Saccharomyces cerevisiae antibody)

Answer

ASCA is found in approximately 60-70% of Crohn's disease patients and is a useful distinguishing marker from UC.

Question 2

What is the primary mechanism of action of vedolizumab in IBD treatment?

Accepted Answer

Gut-selective integrin blockade (anti-α4β7)

Answer

Vedolizumab selectively blocks α4β7 integrin, preventing lymphocyte trafficking specifically to the gut.

Question 3

Which complication of Crohn's disease is characterized by an abnormal connection between two loops of bowel?

Accepted Answer

Entero-enteric fistula

Answer

An entero-enteric fistula is an abnormal passage connecting two segments of intestine, a transmural complication characteristic of Crohn's disease.

Question 4

What is the Montreal Classification used to describe in IBD?

Accepted Answer

Extent and behavior of Crohn's disease and extent of UC

Answer

The Montreal Classification categorizes Crohn's disease by age of onset, location, and behavior, and categorizes UC by extent of involvement.

Question 5

Toxic megacolon is most commonly associated with which condition?

Accepted Answer

Severe ulcerative colitis

Answer

Toxic megacolon, defined as colonic dilation >6 cm with systemic toxicity, is a life-threatening complication most often seen in severe ulcerative colitis.

IBD - Inflammatory Bowel Disease Practice Test

IBD - Inflammatory Bowel Disease Practice Test

IBD Knowledge 2