IBD IBD Complications and Extraintestinal Manifestations

Question 1

Which extraintestinal manifestation of IBD runs a course parallel to (mirrors) intestinal disease activity?

Accepted Answer

Peripheral arthropathy (type 1, pauciarticular)

Answer

Type 1 peripheral arthropathy (pauciarticular, <5 large joints) directly mirrors IBD activity, typically resolving with treatment of the underlying bowel disease.

Question 2

Primary sclerosing cholangitis (PSC) is most strongly associated with which IBD condition?

Accepted Answer

Ulcerative colitis (particularly pancolitis)

Answer

PSC is found in approximately 5% of UC patients, with the converse being true (approximately 75-80% of PSC patients have IBD, predominantly UC with pancolitis).

Question 3

Erythema nodosum in IBD presents as which type of skin lesion?

Accepted Answer

Painful, tender, raised red/purple nodules typically on the anterior shins

Answer

Erythema nodosum presents as painful, erythematous, raised nodules on the anterior shins and typically correlates with IBD activity, resolving with bowel disease treatment.

Question 4

Pyoderma gangrenosum (PG) in IBD differs from erythema nodosum because PG characteristically:

Accepted Answer

May occur independently of IBD activity and requires specific wound care plus immunosuppression

Answer

Unlike erythema nodosum, PG often does not mirror IBD activity, requires specific wound care (wet dressings, avoid aggressive debridement), and needs immunosuppressive therapy.

Question 5

Venous thromboembolism (VTE) risk in IBD patients is elevated primarily because of which mechanism?

Accepted Answer

Hypercoagulable state from chronic inflammation, elevated factor VIII, fibrinogen, and reduced protein C/S

Answer

IBD patients have a 2-3x elevated VTE risk due to chronic inflammation-driven hypercoagulability, elevated acute phase reactants, endothelial dysfunction, and often immobility during flares.

IBD - Inflammatory Bowel Disease Practice Test

IBD - Inflammatory Bowel Disease Practice Test

IBD IBD Complications and Extraintestinal Manifestations