HT Quality Control & Assurance 3

Question 1

Which proficiency testing program is most commonly used by US histology laboratories to satisfy CLIA requirements for nonwaived histopathology testing?

Accepted Answer

College of American Pathologists (CAP) PT surveys

Answer

CAP PT surveys are the most widely used approved proficiency testing program for histopathology in CLIA-regulated US laboratories.

Question 2

When validating a new antibody clone for immunohistochemistry, which tissue should be included as the positive control for Ki-67?

Accepted Answer

Tonsil germinal center

Answer

Tonsil germinal centers contain actively proliferating lymphocytes with high Ki-67 expression, making them ideal positive controls for this proliferation marker.

Question 3

A laboratory's Levey-Jennings chart shows the last 10 control values all falling on the same side of the mean but within 2s limits. Which Westgard rule is violated?

Accepted Answer

10ₓ rule

Answer

The 10ₓ rule is violated when 10 consecutive control values fall on the same side of the mean, indicating a systematic shift or drift in the process.

Question 4

What does a 'six-sigma' quality metric measure in a laboratory process?

Accepted Answer

The process variation relative to acceptable limits, expressed as standard deviations

Answer

Six Sigma measures how many standard deviations fit between the process mean and the nearest specification limit, with higher sigma indicating fewer defects.

Question 5

Which action is required when a CAP inspection reveals that a laboratory has no written policy for reagent expiration dates?

Accepted Answer

File a corrective action report and develop a written policy

Answer

A deficiency found during CAP inspection requires a corrective action report detailing how the deficiency will be resolved, including creation of a written expiration-date policy.

(HT) Histotechnician Certification Practice Test

(HT) Histotechnician Certification Practice Test

HT Quality Control & Assurance 3